The 71-26 vote marked a significant foreign policy achievement for the Obama administration during the lame-duck Congressional session.
Senate Republicans appeared increasingly determined to use the nuclear treaty as a political football in their drive to block all possible administration initiatives.
DREAM Act supporters, both in Congress and at the grassroots, vowed to continue the fight for justice.
The Obama administration stepped up its campaign to overcome a possible Republican filibuster of the DREAM Act.
"Right now we've made a tremendous sacrifice," Secretary of Labor Hilda Solis said. "There's no pleasure in us giving the high income tax bracket these cuts."